“ for developing cryo - electron microscopy for the high - resolution structure determination of biomolecules in solution ” 2017 Nobel Prize in Chemistry
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Mathematics for cryo - electron microscopy
Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubo...
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In 2017, the Nobel Prize in Chemistry was awarded to three key pioneers in the birth and development of cryoelectron microscopy (cryo-EM): Jacques Dubochet, Joachim Frank, and Richard Henderson. As a starting graduate student in England, moving from physics to biology and the study of macromolecular structure, I had the fortune of attending one of the early conferences in the, at the time, embr...
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SPHIRE (SPARX for High-Resolution Electron Microscopy) is a novel open-source, user-friendly software suite for the semi-automated processing of single particle electron cryo-microscopy (cryo-EM) data. The protocol presented here describes in detail how to obtain a near-atomic resolution structure starting from cryo-EM micrograph movies by guiding users through all steps of the single particle ...
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Seeing is believing. So goes the old adage, and seen evidence is undoubtedly satisfying in that it can be interpreted readily, though not necessarily always correctly. For centuries, humans have tried continuously to improve their abilities of seeing things, from developing telescopes to observe our solar systems, to microscopes to reveal bacteria and viruses. The 2014 Nobel Prize in Chemistry ...
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تاریخ انتشار 2017